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Positron Science and BioInorganic Chemistry in the Department of Chemistry
Research InterestsThe specific research interests in my laboratory cover biological inorganic chemistry of various transition metals with biological minerals and materials, mainly peptides and hard tissue. We are interested in exploring the interface between materials and their surface properties. In biominerals, we are interested in using positron annihilation analytical techniques to investigate changes in the nano- and microstructures of teeth, bone and other biological tissues, and in biocompatible materials. Related to biological chemistry, we are also investigating the interactions of positrons with chiral materials. Projects currently underway characterizing chiral crystalline and metal oxide materials using positron techniques, and investigating bonding theory utilizing tension and compression architecture. POSITRON SCIENCE LABORATORY:
My research direction took a large turn toward materials science in 2010,
when Prof. Jerry Jean asked if I would like to take over the positron
group at UMKC upon his retirement.
In addition to polymeric materials regularly studied in that group,
I initiated a research program into the interactions of positrons with
chiral materials, and with biological materials. The shift has consumed a
lot of ‘developmental time’, but this effort is now bearing fruit with the
publication and preparation of papers directed under my research
leadership. Current research
areas (published or forthcoming): A)
Positron interactions with chiral materials – the Positron Science
Laboratory is currently evaluating chiral mineral crystals (quartz) and
other chiral crystalline materials (tartrates) with positron analytical
techniques. Other projects
include bulk and depth profiling of polymers, modified materials, and
layered materials using a suite of positron annihilation lifetime
spectroscopy techniques. B)
Bonding theory – With one student I am exploring mathematical and graph
theoretical approaches to bonding theory.
The basis is the evaluation of tension and compression units
between interacting particles; the theory may be thought of as an
extension of Linnett ‘double quartet’ theory.
Research Areas
BioInorganic Chemistry; Bio-mineral and Bio-material
Structure and Interfacial Characteristics; Chiral Materials; Metal-Peptide
Complexes; Biological Metal Transport; Heavy Metal and Actinide Chemistry;
Positron Annihilation Spectroscopy; Chemical Bonding Theory.
Back to TopPublications)* - Indicates UMKC work. For a high quality copy please contact: vanhornj @ umkc. edu )* Matthew D. Paul, Jonathan S. Davis, Y. C. Jean and J. David Van Horn. “Application and Evaluation of 3D Printed Materials with PALS.” Mat. Sci. Forum. 2016, accepted. )* David Van Horn, Fei Wu, Gerald Corsiglia, and Y. C. Jean. “Asymmetric Positron Interactions with Chiral Quartz Crystals?” Mat. Sci. Forum. 2016, accepted. 028)* J. David Van Horn, Hongmin Chen, Y. C. Jean, Weilong Zhang, Mark R. Jaworowski. “Depth profiles and free volume in aircraft primer films.” J. Phys. Conf. Ser. 2015, 618, 012023. 027)* Zhiyong Xia, Morgana Trexler, Fei Wu, Y. C. Jean, and J. David Van Horn. “Free Volume Hole Relaxation in Molecularly Oriented Polymers.” Phys. Rev. E, 2014, 89, 022603 (12 pp.). 026)* Y. C. Jean, J. David Van Horn, Wei-Song Hung and Kuier-Rarn Lee. “Perspective of positron annihilation spectroscopy in polymers.” Macromolecules 2013, 46, 7133−7145. 025)* J. David Van Horn. Chromium: Physical and chemical properties. In Encyclopedia of Metalloproteins. Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A., Eds. Springer Science, New York, 2013. 024)* J. David Van Horn. Cadmium: Physical and chemical properties. In Encyclopedia of Metalloproteins. Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A., Eds. Springer Science, New York, 2013. 023)* Hongmin Chen, J. David Van Horn and Y. C. Jean. “Applications of Positron Annihilation Spectroscopy to Life Science.” Defect Diffus. Forum. 2012, 331, 275-293. 022) Sridhar Poloju, Kishore Cholkar, Gilles Kouassi, J. David Van Horn, K.S. Rangappa, and Netkal M. Made Gowda. “Oxidation of Lactic Acid by Manganese(III) in Sulfuric Acid Medium: Kinetics and Mechanism.” Am. J. Org. Chem. 2012, 2, 58-62. 021)* J. David Van Horn. “DNA Structure and Supercoiling: Ribbons and a Yo-Yo Model.” J. Chem. Ed. 2011, 81, 1264-1267. 020) Hongmin Ma, Renhao Dong, J. David Van Horn, Jingcheng Hao. “Spontaneous formation of radially aligned microchannels” Chem. Commun. 2011, 47, 2047–2049. 019)* Wei Xie, Ahmed Badawi, Huan Huang and J. David Van Horn. “Interaction of Uranyl Cation with Histidine, Tyrosine and Derivatives.” J. Inorg. Biochem. 2009, 103, 58-63. 018)* Shveta Chaudhary and J. David Van Horn. “Breakdown kinetics of the tri-chromium(III) oxo acetate [Cr3O(Ac)6]+ cluster with some ligands of biological interest.” J. Inorg. Biochem. 2007, 101, 329-335. 017)* Shveta Chaudhary and J. David Van Horn. “Biphasic Kinetics in the Reaction between Amino Acids or Glutathione and the Chromium Acetate Cluster, [Cr3O(OAc)6]+” Mutat. Res. 2006, 610, 56-65. 016)* J. David Van Horn and Huan Huang. “Uranium(VI) Bio-Coordination Chemistry from Biochemical, Solution and Protein Structural Data.” Coord. Chem. Rev. 2006, 250, 765-775. 015)* Xue-Yi Chen, Jerry R. Dias, Doug R. Powell, J. David Van Horn, and Thomas C. Sandreczki. “1,3-Diiodoazulene.” Acta Cryst. E. 2005, E61, o944-o946. 014)* Xue-Yi Chen, Jerry R. Dias, Doug R. Powell, J. David Van Horn, and Thomas C. Sandreczki. “1,3-Dibromoazulene.” Acta Cryst. E. 2005, E61, o941-o943. 013)* Shveta Chaudhary, Joel Pinkston, M. Mohamed Rabile and J. David Van Horn. “Unusual Reactivity in a Commercial Chromium Supplement Compared to Baseline DNA Cleavage with Synthetic and Biomimetic Chromium Complexes.” J. Inorg. Biochem. 2005, 99, 787-794. 012)* Huan Huang, Shveta Chaudhary and J. David Van Horn “Uranyl-Peptide Interactions in Carbonate Solution with DAHK and Derivatives.” Inorg. Chem. 2005, 44, 813-815. 011)* Deendayal Dinakarpandian, Vincent Morrissette, Shveta Chaudhary, Kambiz Amini, Brian Bennett, J. David Van Horn “An informatics search for the low-molecular weight chromium-binding peptide.” BMC Chemical Biology 2004, 4, 2. 010)* Dipesh Ghosh, Douglas R. Powell and J. David Van Horn. “The Cr(III) tris-Malonato Anion with an Organic Cation.” Acta Cryst. E. 2004, E60, m764–m766. 009)* M. Mohamed Rabile, Huan Huang, Dipesh Ghosh, Douglas R. Powell and J. David Van Horn. “2,2’-(Propane-1,3-diimino)dibenzoic acid.” Acta Cryst. E. 2004, E60, o494-o496. 008) J. David Van Horn, Grzegorz Bulaj, David P. Goldenberg and Cynthia J. Burrows “The Cys-Xaa-His Metal-Binding Motif. {N} versus {S} Coordination and Nickel Mediated Formation of Cysteinyl Sulfinic Acid.” J. Biol. Inorg. Chem. 2003, 8, 601-610. 007) Victor L. Heasley, James D. Anderson, Zachary S. Bowman, John C. Hanley, Jr., Geoffery A. Sigmund, David Van Horn, Dale F. Shellhamer “Formation of Dimer-Type Ketals in the Reaction of 2,4,6-Trichlorophenol and 2,4,6-Trichloro-m-cresol with Calcium Hypochlorite in Methanol: Conversion to Quinones and Other Compounds” J. Org. Chem. 2002, 67, 6827-6830. 006) J. David Van Horn, Christine J. Gramer, Brendon O’Sullivan, Kristy M. Clarke Jurchen, Dan M. J. Doble, Kenneth N. Raymond “Iron(III) 2,3-Dihydroxyterephthalamides Revisited. Charge Effects on Highly Stable Ferric Complexes” C. R. Chimie 2002, 5, 395-404. 005) Marguerite Pitié, J. David Van Horn, Denis Brion, Cynthia J. Burrows, and Bernard Meunier “Targeting the DNA Cleavage Activity of Copper Phenanthroline and Clip-Phen to AT Tracts via Linkage to a Poly-N-methylpyrrole.” Bioconj. Chem. 2000, 11, 892-900. 004) J. David Van Horn and Cynthia J. Burrows “Formation of trans-3-Hydroxy-4-phenylbutyrolactone from trans-Styrylacetic Acid and Aqueous KHSO5.” Tetrahedron Lett. 1999, 40, 2069-2070. 003) Robyn P. Hickerson, Victor Duarte, J. David Van Horn, Ronelito J. Perez, James G. Muller, Steven E. Rokita, Cynthia J. Burrows, “DNA Cleavage vs. Crosslinking using Nickel Peptides: Mechanistic Aspects.” In Metals and Genetics; Sarkar, B., Ed.; Plenum: New York, 1999. 002) J. David Van Horn and Thomas G. Richmond “Chiral Ketones for Asymmetric Epoxidations.” Chemtracts: Inorganic Chemistry 1998, 11, 89-94. 001) Victor L. Heasley, Elias, D. S.; Paul E. Erdman, J. David Van Horn, Paul Whitelaw, P. M.; Shellhammer, D. F. “Effects of Pyridine on the Regio- and Stereo-chemistry in the Addition of Bromine Chloride to a,b-unsaturated Aldehydes and Ketones.” J. Chem. Soc., Perkin Trans. 2, 1996, 761-765. Translated Papers
T05)
Shiyu Shen, E. W. Hellmuth and Y. C. Jean.
“The Magnetic Quenching of Positronium (Ps) in PMMA and Epoxy
Polymers. Chinese J. Chem.
Phys. 1993, 6, 139-142. T04) Feng, X.; Rongchang, L. “Binding of Chromium(III) to Human Serum Albumin” Journal of Beijing Medical University (Beijing yike daxue xuebao) 1992, 24, 219-221. Translated by Huan Huang. Edited by J. David Van Horn (PDF) T03) Chevari, S.; Kestkhein, B.; Chevari, M. “Possibilities of rapid elimination of uranium in acute poisoning (An experimental study).” Meditsinskaia radiologiia 1977, 22, 35-40. Translated by Ekaterina N. Kadnikova. Edited by J. David Van Horn (PDF). T02) Chevari, S.; Likhner, D. “A study of the interaction between uranium and certain biocomplexons.” Meditsinskaia radiologiia 1969, 14, 28-34. Translated by Todor Gounev and Ekaterina N. Kadnikova. Edited by J. David Van Horn (PDF). T01) Chevari, S.; Likhner, D. “Complex formation of natural uranium in blood.” Meditsinskaia radiologiia 1968, 13, 53-57. Translated by Todor Gounev and Ekaterina N. Kadnikova. Edited by J. David Van Horn (PDF).
Back to TopProspective Graduate ResearchersUMKC offers a unique Interdisciplinary PhD that allows graduate students to receive cross-disciplinary research and classroom training. Suggested co-Disciplines for students interested in my group are: Molecular Biology and Biochemistry, Pharmaceutical Sciences, Geosciences, Physics, and Cell Biology and Biophysics. You should carefully read the applicable portions of the catalogue to determine what prerequisites are required for a co-discipline. Back to TopProspective Undergraduate ResearchersThere are a number of research topics that an undergraduate researcher can pursue in my labs. Projects range from the synthesis of new compounds or computational chemistry, to analytical chemistry projects and biochemical research projects. Please email me to arrange a meeting to discuss your interests and find out what is going on in the Lab. Students can take CHEM 395, 399, 495 or 499 under my direction, and I hope to have summer research positions ($$) in the near future. Back to TopCopyright © David Van Horn. All rights reserved.
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